Dai et al 2020

Rehabilitation Regimen for Non-Surgical Treatment of Achilles Tendon Rupture.

Early weight bearing and early ankle motion do not impact re-rupture rate

Early weight bearing and ankle motion may prevent severe atrophy and help the reorganization of tenocytes and fibroblasts

Better tendon repair and less atrophy may positively impact rehab duration

Introduction

As recent trials comparing surgical and non-surgical treatment for achilles tendon rupture found no differences in functional outcomes, the latter becomes increasingly investigated. However, little is known on how different non-surgical rehabilitation regimens affect overall recovery. Information on whether they are associated with an increased risk of re-rupture of the tendon is also scarce and that’s what this study is all about! 

Diagram dat chronische achillespees scheurt 1308 8569

 

Methods

The outcome of interest was the re-rupture rate after non-operative treatment. Other relevant outcomes were complication rate (pressure sores, ankle stiffness, tendon unhealed, deep vein thrombosis and pulmonary embolism), functional outcomes (Achilles Tendon Rupture Score – ATRS), quality of life (EQ-5D-5L), return to sports, return to work and the use of resources (total health and personal social care cost). The different rehabilitation regimens included early full weight bearing (start of full weight bearing within 4 weeks after Achilles tendon rupture) versus non-weight bearing and early ankle motion (start of ankle motion within 4 weeks after Achilles tendon rupture) versus ankle immobilization.

 

Results

8 RCTs published between 1992 and 2020 were included and provided data for 978 patients who were followed for 9-54 months (78% males, mean age of 46.1 years (range 21–79 years)). Risk of bias revealed overall good results. However, only 4 of 8 studies adequately blinded the outcome assessment. 2 studies were found to selectively report data. No study blinded participants or clinicians, yet this systematic review indicated that after all this was not possible (total immobilization in a plaster cast versus in a removable functional brace).

Three different rehabilitation regimens were identified across the included studies: 1) Early weight bearing with functional ankle motion, 2) Early weight bearing without functional ankle motion, 3) Ankle immobilisation with non-weight bearing.

Across all outcomes no differences were found when early weight bearing with or without functional ankle motion was compared to ankle immobilization with non-weight bearing. Subgroup analyses revealed no significant differences between the 3 rehabilitation regimens. Early weight bearing with functional ankle motion was associated with a reduced mean cost of £103 compared to ankle immobilization with non-weight bearing, however this was studied by only one study and the confidence interval includes 0 (95% CI: -289 to 84) and should therefore not be interpreted as a real difference.

 

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Talk nerdy to me

Several good aspects can be noted for this systematic review. First of all, a rigorous systematic review was conducted according to the PRISMA guidelines with a prospectively registered protocol. The Cochrane Risk of Bias tool was used to assess bias and showed overall good results. The study analysed data according to the intention-to-treat principle and used a random-effects model. Heterogeneity was assessed and was found to be low in all outcomes but one (complication rate, I-squared=57%). The subgroup analysis for this outcome revealed acceptable heterogeneity, and so this absence of a difference between the subgroups may be interpreted accordingly. The Egger and Begg tests revealed no indication for publication bias. The eligibility of studies was not restricted to the English language and thus it can be assumed that no language bias has influenced the results. 

Only a few limitations can be found for this study, yet they were clearly reported. The type of sports and the type of work in the analyses of return to sports and return to work respectively, lacked homogeneity. This may be an issue since it may make these conclusions less certain. Secondly, the ATRS and the EQ-5D-5L were only investigated in 3 and 2 studies respectively, and therefore it may be possible that a type II statistical error impacted the results (meaning that due to an underpowered analysis the test was not able to detect a true difference).

 

Take home messages

As no differences between weight bearing or non-weight bearing and between functional ankle motion or ankle immobilization were found, it may be concluded that weight bearing and functional ankle motion should be included in the rehabilitation of achilles tendon ruptures. Especially for the primary outcome, one can be confident to initiate early weight bearing and functional ankle motion as it does not impact re-rupture rate. For the other outcomes, we can confidently conclude that early weight bearing and functional ankle motion do not increase complications. We can assume early weight bearing does not negatively impact quality of life, return to sport, return to work and functional outcomes, but this should be interpreted cautiously as heterogeneity and the possibility of an underpowered analysis may have influenced the conclusions.

Early weight bearing may not only give patients more self-care ability, but it may also prevent severe atrophy that occurs with complete immobilization. Therefore it may also be important in the repair process as the mechanical stress administered through weight bearing and ankle motion may help to adequately reorganize fibroblasts and tenocytes in the damaged tendon. As a result, better tendon repair and less loss of strength are likely to occur which may have an significant impact on the (duration of the) recovery process.

Link to the paper: https://pubmed.ncbi.nlm.nih.gov/33388266/