{"id":26134,"date":"2025-10-20T12:00:36","date_gmt":"2025-10-20T10:00:36","guid":{"rendered":"https:\/\/www.physiotutors.com\/?post_type=research&#038;p=26134"},"modified":"2025-12-12T11:39:59","modified_gmt":"2025-12-12T10:39:59","slug":"exercise-for-chronic-ankle-instability","status":"publish","type":"research","link":"https:\/\/www.physiotutors.com\/research\/exercise-for-chronic-ankle-instability\/","title":{"rendered":"Exercise for Chronic Ankle Instability: Best Practices, Duration &amp; Most Effective Techniques"},"featured_media":26135,"template":"","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":""},"featured-tag":[],"tracking_tag":[],"class_list":["post-26134","research","type-research","status-publish","has-post-thumbnail","hentry"],"acf":{"free_access":"unfree","app_link":"https:\/\/app.physiotutors.com\/research-reviews\/exercise-for-chronic-ankle-instability","sections":[{"acf_fc_layout":"page-header-small","background":{"background_image":26135,"background_image_alt_text":""},"heading":"Exercise for Chronic Ankle Instability: Best Practices, Duration &amp; Most Effective Techniques","subheading":"Zhang (2025)","benefits":[{"benefit":"This meta-analysis investigated the best exercise modalities for chronic instability management.  "},{"benefit":"The researchers found that an exercise-based rehabilitation program lasting more than 4 weeks had significantly greater results than no intervention or short-term intervention. "},{"benefit":"Strength training, proprioceptive training and joint mobilization were found to be the most effective treatment approach."}]},{"acf_fc_layout":"content","background_color":"none","content_alignment":"left","content_editor":"<h2><span style=\"font-weight: 400\">Introduction\u00a0<\/span><\/h2>\r\n<span style=\"font-weight: 400\">The ankle is the most frequently injured weight-bearing joint in the body, with ankle sprains being the most common injury type. These typically involve either the lateral ligament complex (especially the anterior talofibular ligament) or, the medial deltoid ligament complex. After an initial sprain, many individuals develop <\/span><b>chronic ankle instability (CAI)<\/b><span style=\"font-weight: 400\"> \u2014 a condition marked by recurrent sprains, instability, pain, weakness, and limited range of motion as described in this <a href=\"https:\/\/www.physiotutors.com\/clinical-patterns\/chronic-ankle-instability\/\" target=\"_blank\" rel=\"noopener\">physiotutors\u2019 clinical pattern<\/a>. <\/span><span style=\"font-weight: 400\">Lateral ankle sprains account for about <\/span><b>73% of all ankle sprains<\/b><span style=\"font-weight: 400\">, and inadequate rehabilitation after the first injury (reported in 50\u201370% of cases) is a major contributor to chronic instability.\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400\">Exercise for chronic ankle instability<\/span><span style=\"font-weight: 400\"> \u2014 including strength, balance, and proprioceptive training \u2014 is considered a cornerstone of rehabilitation and has proven benefits for various chronic conditions. Evidence shows it helps prevent recurrent ankle sprains; however, there is still uncertainty about which specific exercise components are most effective.<\/span>\r\n\r\n<span style=\"font-weight: 400\">Recent studies have highlighted the positive effects of <\/span><b>balance training<\/b><span style=\"font-weight: 400\"> in CAI. Still, existing meta-analyses have methodological limitations (e.g., overlapping control groups or inclusion of mixed exercise interventions), making it difficult to isolate the true effect of different exercise types. To address these gaps, the present <\/span><b>meta-analysis<\/b><span style=\"font-weight: 400\"> aims to evaluate the overall effectiveness of <\/span><span style=\"font-weight: 400\">exercise for chronic ankle instability<\/span><span style=\"font-weight: 400\"> and to compare the relative benefits of different exercise modalities. Importantly, all included control groups were true non-intervention conditions, ensuring cleaner comparisons and more reliable conclusions.<\/span>\r\n<h2><span style=\"font-weight: 400\">Methods\u00a0<\/span><\/h2>\r\n<b>Search Strategy:<\/b>\r\n\r\n<span style=\"font-weight: 400\">Four medical databases were searched. Only English-language RCTs were included. Eligible studies involved participants with chronic ankle instability (CAI), an exercise therapy intervention group, a no-intervention control group, and quantitative outcomes on ankle function (FAAM and SEBT).<\/span>\r\n<h4><b>Study Selection<\/b><\/h4>\r\n<span style=\"font-weight: 400\">Two reviewers independently screened all retrieved titles and abstracts. Studies that appeared relevant were read in full to determine eligibility based on predefined inclusion and exclusion criteria. Disagreements were resolved through discussion or by consulting a third reviewer.<\/span>\r\n\r\n<b>Inclusion criteria<\/b>\r\n<ul>\r\n \t<li style=\"font-weight: 400\"><b>Population:<\/b><span style=\"font-weight: 400\"> Participants explicitly diagnosed with chronic ankle instability (CAI).<\/span><\/li>\r\n \t<li style=\"font-weight: 400\"><b>Intervention:<\/b><span style=\"font-weight: 400\"> The experimental group received <\/span><i><span style=\"font-weight: 400\">exercise therapy<\/span><\/i><span style=\"font-weight: 400\"> (any structured rehabilitation, balance, or strengthening program).<\/span><\/li>\r\n \t<li style=\"font-weight: 400\"><b>Control:<\/b><span style=\"font-weight: 400\"> The comparison group received <\/span><i><span style=\"font-weight: 400\">no intervention<\/span><\/i><span style=\"font-weight: 400\"> (no exercise, placebo, or standard care without structured exercise).<\/span><\/li>\r\n \t<li style=\"font-weight: 400\"><b>Outcomes:<\/b><span style=\"font-weight: 400\"> Studies provided quantitative data assessing ankle function using validated measures \u2014 specifically the <\/span><i><span style=\"font-weight: 400\">Foot and Ankle Ability Measure<\/span><\/i><span style=\"font-weight: 400\"> (FAAM) and\/or the <\/span><i><span style=\"font-weight: 400\">Star Excursion Balance Test<\/span><\/i><span style=\"font-weight: 400\"> (SEBT).<\/span><\/li>\r\n \t<li style=\"font-weight: 400\"><b>Study Design:<\/b><span style=\"font-weight: 400\"> Only randomized controlled trials (RCTs) were included to ensure high-quality evidence.<\/span><\/li>\r\n<\/ul>\r\n<b>Exclusion criteria<\/b>\r\n<ul>\r\n \t<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Participants with acute ankle injuries or non-chronic instability conditions.<\/span><\/li>\r\n \t<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Non-original studies such as abstracts, conference proceedings, editorials, expert opinions, reviews, case reports, or laboratory-based studies.<\/span><\/li>\r\n \t<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Non-English publications or articles lacking full text.<\/span><\/li>\r\n<\/ul>\r\n<h4><b>Outcome Measures<\/b><\/h4>\r\n<ul>\r\n \t<li style=\"font-weight: 400\"><b>Functional performance:<\/b> <i><span style=\"font-weight: 400\">Foot and Ankle Ability Measure<\/span><\/i><span style=\"font-weight: 400\"> \u2013\u00a0 A self-reported ankle instability questionnaire consisting of two parts: Activities of Daily Living (FAAM-ADL) and Sports (FAAM-S). The FAAM is scored from 0 to 100%, with higher results corresponding to greater function.\u00a0<\/span><\/li>\r\n \t<li><b>Dynamic balance:<\/b> <a href=\"https:\/\/www.physiotutors.com\/wiki\/star-excursion-balance-test\/\" target=\"_blank\" rel=\"noopener\"><i><span style=\"font-weight: 400\">Star Excursion Balance Test<\/span><\/i><\/a><span style=\"font-weight: 400\"> (SEBT) across eight directions anterior (A), antero-medial (AM), antero-lateral (AL), medial (M), lateral\u00a0 (L), posterior (P), postero-medial (PM), postero-lateral (PL).<\/span><\/li>\r\n<\/ul>\r\n<h4><b>Data Extraction<\/b><\/h4>\r\n<span style=\"font-weight: 400\">Two reviewers independently extracted study characteristics and outcome data using a standardized form. Studies were grouped into:<\/span>\r\n<ul>\r\n \t<li style=\"font-weight: 400\"><b>Exercise therapy group<\/b><span style=\"font-weight: 400\"> (intervention)<\/span><\/li>\r\n \t<li style=\"font-weight: 400\"><b>Blank control group<\/b><span style=\"font-weight: 400\"> (no intervention)<\/span><\/li>\r\n<\/ul>\r\n<span style=\"font-weight: 400\">All outcomes were continuous variables. For outcomes using the same units, mean difference (MD) and 95% confidence interval (CI) were calculated; otherwise, standardized <\/span><span style=\"font-weight: 400\">mean difference (SMD) was used. Authors were contacted when key numerical data (mean or SD) were missing.<\/span>\r\n<h4><b>Risk of Bias and Quality Assessment<\/b><\/h4>\r\n<span style=\"font-weight: 400\">Methodological quality was assessed using the Cochrane Risk of Bias Tool (RoB 2). The GRADE framework (via <\/span><i><span style=\"font-weight: 400\">GRADE Profiler 3.0<\/span><\/i><span style=\"font-weight: 400\">) was used to rate the overall strength of evidence for main outcomes as <\/span><i><span style=\"font-weight: 400\">High<\/span><\/i><span style=\"font-weight: 400\">, <\/span><i><span style=\"font-weight: 400\">Moderate<\/span><\/i><span style=\"font-weight: 400\">, <\/span><i><span style=\"font-weight: 400\">Low<\/span><\/i><span style=\"font-weight: 400\">, or <\/span><i><span style=\"font-weight: 400\">Very Low<\/span><\/i><span style=\"font-weight: 400\">.<\/span>\r\n\r\n<b>Statistical analyses\u00a0<\/b>\r\n\r\n<span style=\"font-weight: 400\">Results were expressed as mean difference (MD) or standardized mean difference (SMD) with 95% confidence intervals (CI).<\/span>\r\n\r\n<span style=\"font-weight: 400\">Heterogeneity\u2014the degree of variation between study results\u2014was assessed using the <\/span><i><span style=\"font-weight: 400\">I\u00b2 statistic<\/span><\/i><span style=\"font-weight: 400\">. If variation was low (<\/span><i><span style=\"font-weight: 400\">I\u00b2 &lt; 50%<\/span><\/i><span style=\"font-weight: 400\">), a fixed-effects model was used; if high (<\/span><i><span style=\"font-weight: 400\">I\u00b2 \u2265 50%<\/span><\/i><span style=\"font-weight: 400\">), a random-effects model was chosen to account for differences among studies.<\/span>\r\n\r\n<span style=\"font-weight: 400\">To test the stability of results, a sensitivity analysis was performed by removing individual studies to see if outcomes changed. When enough data were available (\u226510 studies), subgroup and meta-regression analyses explored factors that might explain result differences (e.g., exercise type or study quality). Funnel plots were used to check for publication bias. Statistical significance was set at <\/span><i><span style=\"font-weight: 400\">p &lt; 0.05<\/span><\/i><span style=\"font-weight: 400\">.<\/span>\r\n<h2><span style=\"font-weight: 400\">Results\u00a0<\/span><\/h2>\r\n<b>Study selection\u00a0<\/b>\r\n\r\n<span style=\"font-weight: 400\">From 1,607 records initially identified, 1,062 remained after removing duplicates. After title, abstract, and full-text screening, <\/span><b>16 studies<\/b><span style=\"font-weight: 400\"> met the inclusion criteria and were included in the meta-analysis.<\/span>\r\n\r\n[caption id=\"attachment_26136\" align=\"alignnone\" width=\"505\"]<img class=\"size-full wp-image-26136\" src=\"https:\/\/www.physiotutors.com\/wp-content\/uploads\/2025\/10\/Flow-chart-.jpg\" alt=\"Exercise for chronic ankle instability\" width=\"505\" height=\"653\" \/> From: Zhang et al., Sci Rep Nature (2025).[\/caption]\r\n\r\n<b>Risk of bias assessment\u00a0<\/b>\r\n\r\n<span style=\"font-weight: 400\">Overall, the included studies showed generally good methodological quality, as assessed with the Cochrane RoB 2 tool. Most trials reported clear randomization methods, appropriate intervention procedures, and complete outcome data. However, a few studies had unclear randomization processes or lack of blinding of outcome assessors, which introduced some risk of bias.<\/span>\r\n\r\n<span style=\"font-weight: 400\">In total, 11 studies were rated as low risk, one raised some concerns, and three were considered high risk. A detailed breakdown of bias across each domain is presented in Figure 2.<\/span>\r\n\r\n[caption id=\"attachment_26137\" align=\"alignnone\" width=\"1090\"]<img class=\"wp-image-26137 size-full\" src=\"https:\/\/www.physiotutors.com\/wp-content\/uploads\/2025\/10\/Risk-of-Bias-.jpg\" alt=\"Exercise for chronic ankle instability\" width=\"1090\" height=\"595\" \/> From: Zhang et al., Sci Rep Nature (2025).[\/caption]\r\n\r\n<b>Meta-analysis results - FAAM\u00a0<\/b>\r\n\r\n<span style=\"font-weight: 400\">Six studies investigated the impact of <\/span><span style=\"font-weight: 400\">exercise for chronic ankle instability<\/span><span style=\"font-weight: 400\"> on self-reported functional assessment in patients with chronic ankle instability, using the Foot and Ankle Ability Measure (FAAM) for both the Activities of Daily Living (FAAM-ADL) and Sports (FAAM-Sports) subscales.<\/span>\r\n\r\n<span style=\"font-weight: 400\">The meta-analysis showed that <\/span><span style=\"font-weight: 400\">exercise for chronic ankle instability<\/span><span style=\"font-weight: 400\"> therapy significantly improved self-reported ankle function on both measures. Initial analyses revealed high heterogeneity (I<\/span><span style=\"font-weight: 400\">2<\/span><span style=\"font-weight: 400\">= 68%)among studies for FAAM-ADL, but further sub-grouping investigation indicated that intervention duration was a key factor \u2014 <\/span><b>programs lasting longer than four weeks produced more consistent and superior improvements compared to shorter interventions. <\/b><span style=\"font-weight: 400\">Detailed results and subgroup analyses are presented in Figure 3.<\/span>\r\n\r\n[caption id=\"attachment_26138\" align=\"alignnone\" width=\"874\"]<img class=\"wp-image-26138 size-full\" src=\"https:\/\/www.physiotutors.com\/wp-content\/uploads\/2025\/10\/Fig-3-meta-analysis-.jpg\" alt=\"Exercise for chronic ankle instability\" width=\"874\" height=\"635\" \/> From: Zhang et al., Sci Rep Nature (2025).[\/caption]\r\n\r\n<b>Meta-analysis Results \u2013 Dynamic Balance (SEBT)<\/b>\r\n\r\n<span style=\"font-weight: 400\">Eleven studies evaluated the effects of <\/span><span style=\"font-weight: 400\">exercise for chronic ankle instability<\/span><span style=\"font-weight: 400\"> on dynamic balance in patients with chronic ankle instability using the Star Excursion Balance Test (SEBT) across the eight directions.<\/span>\r\n\r\n<span style=\"font-weight: 400\">Overall, exercise therapy led to significant improvements in most SEBT directions, showing that such programs effectively enhance balance control and postural stability. However, no significant differences were found in the anterolateral and lateral directions. Interestingly, after removing two studies for sensitivity analysis purposes, the results for SEBT anteromedial direction became non-significant.\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400\">Although high heterogeneity existed between studies, the benefits of exercise therapy remained consistent, particularly in the anterior, posteromedial, and posterolateral directions. Sensitivity analyses confirmed that the positive effects persisted even when individual studies were excluded.<\/span>\r\n\r\n<span style=\"font-weight: 400\">Further subgroup and meta-regression analyses were conducted to investigate the source of heterogeneity. Three subgroups were defined:<\/span><b> intervention duration<\/b><span style=\"font-weight: 400\"> (&lt; or &gt;4 weeks), <\/span><b>exercise type<\/b><span style=\"font-weight: 400\"> (proprioception, strengthening, neuromuscular activation or joint mobilization) and <\/span><b>country<\/b><span style=\"font-weight: 400\">. Detailed results and subgroup comparisons are presented in Figure 4.<\/span>\r\n\r\n<img class=\"alignnone size-full wp-image-26139\" src=\"https:\/\/www.physiotutors.com\/wp-content\/uploads\/2025\/10\/fig-4-meta-analysis-SEBT1.jpg\" alt=\"Exercise for chronic ankle instability\" width=\"825\" height=\"899\" \/>\r\n\r\n[caption id=\"attachment_26140\" align=\"alignnone\" width=\"1085\"]<img class=\"wp-image-26140 size-full\" src=\"https:\/\/www.physiotutors.com\/wp-content\/uploads\/2025\/10\/fig4-SEBT2.jpg\" alt=\"Exercise for chronic ankle instability\" width=\"1085\" height=\"781\" \/> From: Zhang et al., Sci Rep Nature (2025).[\/caption]\r\n<h3><b>Meta-regression and Subgroup Analysis Results<\/b><\/h3>\r\n<span style=\"font-weight: 400\">Meta-regression analysis was conducted to explore potential sources of variation between studies. No significant subgroup differences were identified (p &gt; 0.05), suggesting that the observed heterogeneity was not explained by study-level factors such as country, intervention duration, or exercise type. Because most studies originated from the United States, country-based comparisons were considered less meaningful.<\/span>\r\n\r\n<span style=\"font-weight: 400\">Subgroup analyses focused on <\/span><b>intervention duration<\/b><span style=\"font-weight: 400\"> and <\/span><b>exercise type<\/b><span style=\"font-weight: 400\">. The findings indicated that <\/span><b>programs lasting longer than four weeks<\/b><span style=\"font-weight: 400\"> produced more consistent and greater improvements in dynamic balance (SEBT A, PL and PM) compared to shorter interventions. Shorter programs (\u22644 weeks) showed benefits only for SEBT PM and PL directions.<\/span>\r\n\r\n<span style=\"font-weight: 400\">Overall, these results suggest that <\/span><b>longer exercise interventions are more effective<\/b><span style=\"font-weight: 400\"> for improving balance in patients with chronic ankle instability, although results should be interpreted cautiously due to remaining heterogeneity.\u00a0<\/span>\r\n<h3><b>Sensitivity Analysis of Intervention Period Subgroups<\/b><\/h3>\r\n<span style=\"font-weight: 400\">Because the subgroup analyses still showed high heterogeneity, a sensitivity analysis was performed by removing individual studies one at a time. The results showed that heterogeneity dropped substantially \u2014 or even disappeared \u2014 after excluding certain studies. Specifically, removing Cruz-Diaz et al. (2014) eliminated variability in SEBT-PL (\u22644<\/span>\r\n\r\n<span style=\"font-weight: 400\">weeks), and removing Chang et al. (2021) did the same for SEBT-A and SEBT-PL (&gt;4 weeks). Excluding Lapanantasin et al. (2022) reduced heterogeneity in SEBT-PM and SEBT-PL (\u22644 weeks), while removing Reyes et al. eliminated heterogeneity in SEBT-PM (&gt;4 weeks).<\/span>\r\n<h3><b>Exercise Type Subgroup Analysis<\/b><\/h3>\r\n<span style=\"font-weight: 400\">Strength training significantly enhanced SEBT performance in the posteromedial and posterolateral directions, while proprioceptive training produced similar benefits. Joint mobilization improved balance across anterior, posteromedial and posterolateral directions.\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400\">Neuromuscular activation exercises, such as whole-body vibration training, led to moderate improvements, particularly in the PL direction, though results were less consistent across studies. Proprioceptive training also led to notable improvements in SEBT-PM and SEBT-PL<\/span>\r\n\r\n<span style=\"font-weight: 400\">A sensitivity analysis showed that removing certain studies (notably those by Chang et al. and Lapanantasin et al.) reduced heterogeneity without changing the overall findings. This suggests that while the type of exercise contributes to variability, the overall conclusions remain robust. However, the effects of neuromuscular activation on SEBT outcomes should be interpreted with caution due to inconsistent evidence.<\/span>\r\n<h3><b>Efficacy Validation of Exercise Therapy<\/b><\/h3>\r\n<span style=\"font-weight: 400\">To compare the relative effectiveness of different exercise types, indirect comparisons were made using the control group as a common reference. Indirect comparisons were conducted for studies including SEBT-A, SEBT-PM and SEBT-PL. Surface Under the Cumulative Ranking Curve, and pairwise comparison forest plot are displayed in Figure 5 and will be further discussed in the Talk nerdy to me section.\u00a0<\/span>\r\n\r\n<span style=\"font-weight: 400\">The results, illustrated in Figure 5, show that:<\/span>\r\n<ul>\r\n \t<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">For <\/span><b>SEBT-A (anterior direction)<\/b><span style=\"font-weight: 400\">, <\/span><b>joint mobilization<\/b><span style=\"font-weight: 400\"> was the most effective, followed by <\/span><b>strength training<\/b><span style=\"font-weight: 400\">, both showing significant improvements compared to the control group.<\/span><\/li>\r\n \t<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">For <\/span><b>SEBT-PM (posteromedial direction)<\/b><span style=\"font-weight: 400\">, <\/span><b>strength training<\/b><span style=\"font-weight: 400\"> and <\/span><b>proprioceptive training<\/b><span style=\"font-weight: 400\"> produced the greatest improvements, significantly outperforming other exercise types.<\/span><\/li>\r\n \t<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">For <\/span><b>SEBT-PL (posterolateral direction)<\/b><span style=\"font-weight: 400\">, <\/span><b>strength training<\/b><span style=\"font-weight: 400\"> again showed the best results, followed by <\/span><b>proprioceptive<\/b><span style=\"font-weight: 400\"> and <\/span><b>neuromuscular<\/b><span style=\"font-weight: 400\"> training.<\/span><\/li>\r\n<\/ul>\r\n<span style=\"font-weight: 400\">Overall, these findings suggest that joint mobilization is most effective for improving anterior balance, while strength and proprioceptive training yield the greatest benefits for posterior balance stability in individuals with chronic ankle instability.<\/span>\r\n\r\n<img class=\"alignnone size-full wp-image-26141\" src=\"https:\/\/www.physiotutors.com\/wp-content\/uploads\/2025\/10\/SUCRA-1-.jpg\" alt=\"Exercise for chronic ankle instability\" width=\"1067\" height=\"722\" \/>\r\n\r\n[caption id=\"attachment_26142\" align=\"alignnone\" width=\"1137\"]<img class=\"wp-image-26142 size-full\" src=\"https:\/\/www.physiotutors.com\/wp-content\/uploads\/2025\/10\/SUCRA-2.jpg\" alt=\"Exercise for chronic ankle instability\" width=\"1137\" height=\"486\" \/> From: Zhang et al., Sci Rep Nature (2025).[\/caption]\r\n<h3><b>Publication Bias and Quality of Evidence<\/b><\/h3>\r\n<span style=\"font-weight: 400\">A funnel plot analysis was performed for SEBT outcomes (see Figure 6). The plot showed a generally symmetrical distribution, suggesting that publication bias was minimal.<\/span>\r\n\r\n[caption id=\"attachment_26143\" align=\"alignnone\" width=\"872\"]<img class=\"wp-image-26143 size-full\" src=\"https:\/\/www.physiotutors.com\/wp-content\/uploads\/2025\/10\/Risk-of-bias-fig-6.jpg\" alt=\"Exercise for chronic ankle instability\" width=\"872\" height=\"628\" \/> From: Zhang et al., Sci Rep Nature (2025).[\/caption]\r\n\r\n<span style=\"font-weight: 400\">Using the GRADE approach (see Table 4), the overall quality of evidence across all outcomes was rated as low to very low, mainly due to high heterogeneity among studies and small sample sizes.<\/span>\r\n\r\n[caption id=\"attachment_26144\" align=\"alignnone\" width=\"977\"]<img class=\"wp-image-26144 size-full\" src=\"https:\/\/www.physiotutors.com\/wp-content\/uploads\/2025\/10\/Table-4-GRADE.jpg\" alt=\"Exercise for chronic ankle instability\" width=\"977\" height=\"481\" \/> From: Zhang et al., Sci Rep Nature (2025).[\/caption]\r\n<h2><span style=\"font-weight: 400\">Questions and thoughts\u00a0<\/span><\/h2>\r\n<span style=\"font-weight: 400\">The authors do not specify how chronic ankle instability (CAI) was defined in the included studies. Criteria such as chronicity or clinical features required for CAI diagnosis are not described, which may have contributed to heterogeneity in participant characteristics and influenced the results.<\/span>\r\n\r\n<span style=\"font-weight: 400\">While the FAAM and SEBT are valuable tools for assessing functional improvement in patients with CAI, they may not fully capture the overall effectiveness of <\/span><span style=\"font-weight: 400\">exercise for chronic ankle instability<\/span><span style=\"font-weight: 400\">. Including outcomes such as strength or the recurrence rate of ankle sprains would have provided a more comprehensive picture of long-term efficacy. Reporting odds ratios for recurrence could also have strengthened the interpretation of exercise effectiveness. Overall, the scope feels somewhat limited for evaluating rehabilitation success.<\/span>\r\n\r\n<span style=\"font-weight: 400\">Regarding the comparison of exercise modalities, it is debatable whether isolating interventions\u2014such as strength, neuromuscular, or proprioceptive training\u2014reflects real-world clinical practice. These elements are often integrated rather than applied independently. Future studies should focus on structured, individualized rehabilitation programs that target specific deficits and follow objective-led progression, rather than comparing single exercise types against generic protocols.<\/span>\r\n\r\n<span style=\"font-weight: 400\">Finally, one methodological limitation of this meta-analysis lies in its design: since the control groups received no intervention, participants and assessors could not be blinded, which introduces a potential performance and detection bias.<\/span>\r\n<h2><span style=\"font-weight: 400\">Talk nerdy to me\u00a0<\/span><\/h2>\r\n<span style=\"font-weight: 400\">In Figures 3 and 4, the forest plots may appear slightly misleading at first glance, as most of the green boxes (representing each study\u2019s mean difference) are positioned on the \u201cFavours no intervention\u201d side. However, this does not indicate that no intervention was superior for FAAM-S or SEBT outcomes. The apparent reversal likely arises from the way the mean difference was calculated \u2014 using the formula (intervention group mean \u2013 control group mean). As a result, positive values represent greater improvement in the exercise group, even though they are displayed on the \u201cFavours no intervention\u201d side of the graph.<\/span>\r\n\r\n<span style=\"font-weight: 400\">To compare the different exercise interventions with each other, the authors used the Surface Under the Cumulative Ranking Curve (SUCRA) analysis. This approach is commonly applied in network meta-analyses to rank several interventions based on their relative efficacy, even when not all have been directly compared in individual studies. The SUCRA value, displayed in Figure 5, represents the probability that a treatment is among the most effective options, with larger areas indicating greater effectiveness. This method helps visualize which exercise type performs best across all available evidence for SEBT\u2013A, SEBT\u2013PM, and SEBT\u2013PL outcomes.<\/span>\r\n\r\n<span style=\"font-weight: 400\">In Panel A, which shows the results for SEBT\u2013A, the SUCRA plot (left) and the pairwise comparison forest plot (right) together illustrate the relative performance of each exercise type. The SUCRA curves indicate that joint mobilization had the highest probability of being the most effective intervention for improving SEBT\u2013A scores, followed by strength training, while neuromuscular activation, proprioceptive training, and control ranked lower. In the forest plot, a positive mean difference (MD) means the first intervention achieved higher SEBT\u2013A values than the second, whereas a negative MD favors the second intervention. Confidence intervals (CIs) that do not cross zero indicate statistically significant differences. For example, joint mobilization vs proprioceptive training (MD = +8.58, 95% CI: 2.16\u201315.00) significantly favors joint mobilization, confirming its superior efficacy. In contrast, neuromuscular activation vs strength training (MD = \u20131.02, 95% CI: \u20134.57\u20132.54) shows no significant difference between these two interventions.<\/span>\r\n<h2><span style=\"font-weight: 400\">Take Home messages\u00a0<\/span><\/h2>\r\n<ul>\r\n \t<li style=\"font-weight: 400\"><b>Exercise therapy works.<\/b><span style=\"font-weight: 400\"> Structured exercise programs significantly improve self-reported function (FAAM) and dynamic balance (SEBT) in patients with chronic ankle instability (CAI), confirming its central role in rehabilitation.<\/span><\/li>\r\n \t<li style=\"font-weight: 400\"><b>Program duration matters.<\/b><span style=\"font-weight: 400\"> Interventions lasting <\/span><b>more than four weeks<\/b><span style=\"font-weight: 400\"> produce greater and more consistent improvements, particularly in the <\/span><b>posterior balance directions<\/b><span style=\"font-weight: 400\"> (posteromedial and posterolateral).<\/span><\/li>\r\n \t<li style=\"font-weight: 400\"><b>Exercise type influences outcomes.<\/b>\r\n<ul>\r\n \t<li style=\"font-weight: 400\"><b>Strength and proprioceptive training<\/b><span style=\"font-weight: 400\"> are most effective for enhancing posterior stability.<\/span><\/li>\r\n \t<li style=\"font-weight: 400\"><b>Joint mobilization<\/b><span style=\"font-weight: 400\"> shows superior effects on <\/span><b>anterior balance<\/b><span style=\"font-weight: 400\">.<\/span><\/li>\r\n<\/ul>\r\n<\/li>\r\n \t<li style=\"font-weight: 400\"><b>Combine, don\u2019t isolate.<\/b><span style=\"font-weight: 400\"> In clinical practice, integrating multiple exercise components\u2014strength, proprioception, neuromuscular control, and joint mobility\u2014may yield the most functional benefits.<\/span><\/li>\r\n \t<li style=\"font-weight: 400\"><b>Evidence quality is low to very low<\/b><span style=\"font-weight: 400\">, largely due to small samples and methodological differences, but the overall direction of findings strongly supports <\/span><b>active rehabilitation<\/b><span style=\"font-weight: 400\"> over no intervention.<\/span><\/li>\r\n<\/ul>\r\n<b>Clinical takeaway:<\/b><b><\/b><span style=\"font-weight: 400\">For managing Chronic Ankle Instability, implement multi-modal <\/span><span style=\"font-weight: 400\">exercise for chronic ankle instability<\/span><span style=\"font-weight: 400\"> of 4+ weeks duration. Key components include strength, proprioception, and mobilization to achieve the primary goals: restoring balance, reducing recurrence rates, and enhancing long-term functional outcomes. Dive deeper into the rationale with this <a href=\"https:\/\/www.youtube.com\/watch?v=MNUMUKPVRHI\" target=\"_blank\" rel=\"noopener\">Physiotutors podcast<\/a> on ankle sprain management<\/span>\r\n<h2><span style=\"font-weight: 400\">Reference<\/span><\/h2>\r\n<a href=\"https:\/\/doi.org\/10.1038\/s41598-025-95896-w\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400\">Zhang, C., Luo, Z., Wu, D. <\/span><i><span style=\"font-weight: 400\">et al.<\/span><\/i><span style=\"font-weight: 400\"> Effectiveness of exercise therapy on chronic ankle instability: a meta-analysis. <\/span><i><span style=\"font-weight: 400\">Sci Rep<\/span><\/i><span style=\"font-weight: 400\"> 15, 11709 (2025). <\/span><\/a>"},{"acf_fc_layout":"cta-big","heading":"THE ROLE OF THE VMO &amp; QUADS IN PFP","subheading":"2 FREE VIDEO LECTURES","content_editor":"Watch this\u00a0<strong>FREE 2-PART\u00a0VIDEO LECTURE<\/strong>\u00a0by knee pain expert\u00a0<strong>Claire Robertson<\/strong>\u00a0who dissects the literature on the topic and how it<strong>\u00a0impacts clinical practice<\/strong>.","form_toggle":true,"form":"96","number_of_buttons":"zero","button_1":{"button_1_button_type":"internal_link","button_1_button_label":"","button_1_button_style":"button-one : 1","button_1_button_internal_link":null,"button_1_button_anchor":"","button_1_button_url":"","button_1_button_file":null},"button_2":{"button_2_button_type":"internal_link","button_2_button_label":"","button_2_button_style":"button-one : 1","button_2_button_internal_link":null,"button_2_button_anchor":"","button_2_button_url":"","button_2_button_file":null},"image":9870,"image_alt_text":"","overlay":false},{"acf_fc_layout":"author","author":{"":null,"image":23638,"image_alt_text":"","name":"F\u00e9lix Bouchet","function_or_description":"My goal is to bridge the gap between research and clinical practice. Through knowledge translation, I aim to empower physiotherapists by sharing the latest scientific data, fostering critical analysis, and breaking down the methodological patterns of studies. By promoting a deeper understanding of research, I strive to improve the quality of care we provide and strengthen the legitimacy of our profession within the healthcare system."}}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Top Evidence-Based Exercise for Chronic Ankle Instability - Physiotutors<\/title>\n<meta name=\"description\" content=\"This systematic review examines best practices and exercise for chronic ankle instability to identify effective rehabilitation strategies.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.physiotutors.com\/research\/exercise-for-chronic-ankle-instability\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Top Evidence-Based Exercise for Chronic Ankle Instability - Physiotutors\" \/>\n<meta property=\"og:description\" content=\"This systematic review examines best practices and exercise for chronic ankle instability to identify effective rehabilitation strategies.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.physiotutors.com\/research\/exercise-for-chronic-ankle-instability\/\" \/>\n<meta property=\"og:site_name\" content=\"Physiotutors\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/facebook.com\/physiotutors\" \/>\n<meta property=\"article:modified_time\" content=\"2025-12-12T10:39:59+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.physiotutors.com\/wp-content\/uploads\/2025\/10\/SITE-IMAGE-2.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"3960\" \/>\n\t<meta property=\"og:image:height\" content=\"1760\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@physiotutors\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.physiotutors.com\\\/research\\\/exercise-for-chronic-ankle-instability\\\/\",\"url\":\"https:\\\/\\\/www.physiotutors.com\\\/research\\\/exercise-for-chronic-ankle-instability\\\/\",\"name\":\"Top Evidence-Based Exercise for Chronic Ankle Instability - Physiotutors\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.physiotutors.com\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.physiotutors.com\\\/research\\\/exercise-for-chronic-ankle-instability\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.physiotutors.com\\\/research\\\/exercise-for-chronic-ankle-instability\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.physiotutors.com\\\/wp-content\\\/uploads\\\/2025\\\/10\\\/SITE-IMAGE-2.jpg\",\"datePublished\":\"2025-10-20T10:00:36+00:00\",\"dateModified\":\"2025-12-12T10:39:59+00:00\",\"description\":\"This systematic review examines best practices and exercise for chronic ankle instability to identify effective rehabilitation strategies.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.physiotutors.com\\\/research\\\/exercise-for-chronic-ankle-instability\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.physiotutors.com\\\/research\\\/exercise-for-chronic-ankle-instability\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.physiotutors.com\\\/research\\\/exercise-for-chronic-ankle-instability\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.physiotutors.com\\\/wp-content\\\/uploads\\\/2025\\\/10\\\/SITE-IMAGE-2.jpg\",\"contentUrl\":\"https:\\\/\\\/www.physiotutors.com\\\/wp-content\\\/uploads\\\/2025\\\/10\\\/SITE-IMAGE-2.jpg\",\"width\":3960,\"height\":1760,\"caption\":\"Exercise for chronic ankle instability\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.physiotutors.com\\\/research\\\/exercise-for-chronic-ankle-instability\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.physiotutors.com\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Exercise for Chronic Ankle Instability: Best Practices, Duration &amp; 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